Most lubricant available on the market is mineral based and synthetic. Several researchers tried to improve the tribological behavior of lubricating oil and one of the methods is adding a suitable additive in the lubricant. The present work investigated the tribological behavior properties of CuO nanoparticles in SYNTIUM 800 SL 10W-30 and nanoparticle added were dispersed using a sonicator water bath and oleic acid as the surfactant for improved dispensability and stability of nano lubricant. All the test were performed under different parameter (load, concentration, and speed) moreover, RSM method has been used for the design of the experiment. The evaluated of the friction and wear properties between the moving testers were analysis the surface and composition at the specimen using the SEM and XDR. TEM also been used to investigate the agglomeration and stability of the lubricant consist additive. The result shows that the CuO nanoparticles can effectively improve the engine oil lubricating properties and at the same time improve the tribological behavior were reduce the coefficient of friction and wear under certain condition. It found that the addition of CuO nanoparticles is most effective nanoparticles in the lubricant were appeared the protection film for reduction the tribological behavior at some limitation and other characteristics of the CuO additive.